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Even if short-term treatment with corticosteroids does not cause clinically significant toxicity, recurrent or long-term treatment may have deleterious effectson the host. The treatment of tuberculosis with glucocorticoids has a low recurrence rate but can lead to permanent disability and life-long complications, including lung disease, cardiac infection, and endocrine and immune malfunction [11]. Corticosteroid therapy is also sometimes prescribed in the diagnosis of asthma and other asthma-related conditions. However, there are other potentially different outcomes when corticosteroids are used in asthma. For example, if the long-acting injectable form of corticosteroids produces systemic effects by blocking the activity of the histamine-related protein HPA, there is increased risk of respiratory symptoms when applied topically, which is an important consideration in asthma treatment [35]. It is very important to note that even in patients who develop pulmonary edema and worsening asthma symptoms when given glucocorticoids and the oral steroid methotrexate, most of these individuals have a positive association with atopy in their family history [36]. In addition, there is a high incidence of hypothyroidism in patients with asthma. Therefore, it seems important to consider the possible interaction of hypothyroidism and corticosteroid therapy with the treatment of asthma and, if applicable, to consider using alternative asthma antihistamines. In summary, there are potential interactions between corticosteroids and asthma medications, and corticosteroid use is associated with a large number of adverse effects, including increased risk of diabetes, hypertension, and the development of other health problems, as well as the need to discontinue treatment. The use of corticosteroids is recommended in patients who experience persistent asthma symptoms despite other therapy. If the patient has a history of asthma, a comprehensive review of the evidence is recommended to assess the need for a medication change. A multichannel approach is also recommended on behalf of health care providers including allergy, infectious disease, and mental health professionals (Table S1). Treatments for asthma that may be used to treat patients with asthma include inhaled steroids such as prednisone [1, 37]. Prednisone was initially used as an adjuvant for the treatment of asthma. In retrospect, the use of prednisone has been associated with a wide range of adverse effects including liver toxicity and respiratory depression in patients with asthma [5, 39]. There have been recent concerns raised about the use of prednisone in asthma therapy and its long-term effects with asthma. A comprehensive review of the evidence by the Institute of Medicine ( Related Article:
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